Introduction of a new synthetic route about

Application of 5049-61-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5049-61-6 name is Pyrazin-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of pyrazin-2-ylamine (6.66 g, 70 mmol) in CH2Cl2 (200 mL) was cooled to 00C, treated with N-bromosuccinamide (12.5 EPO g, 70 mmol) and allowed to warm to room temperature. The resulting reaction mixture was stirred overnight, then diluted with additional CH2Cl2 (200 mL) and washed with 10% aqueous Na2CO3 solution. The layers were separated, and the organic layer washed with sat’d aqueous NaCl solution, then dried over anhydrous MgSO4 filtered, and concentrated under reduced pressure. The residue was taken up in EtOAc (50 mL) and the product was precipitated by the addition of hexane (300 mL) . The precipitate was dried under vacuum to yield 5.57 g of a tan solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; ICOS CORPORATION; WO2006/105262; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem