875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Bromo-5H-pyrrolo[2,3-b]pyrazine
2-bromo-5H-pyrrolo[2,3-b]pyrazine (5 g, 25 mmol) was added to chlorosulfonic acid (20 mL) at 0C. The reaction was heated to 100-120C for 2.5 hours before cooling and pouring into ice-water (80 mL). The solution was extracted into EtOAc (2 x 100 mL), the organic layers combined, washed with brine, dried over sodium sulphate and concentrated in vacuo. The residue was added to a solution of isopropylamine (881 mg, 15 mmol) and triethylamine (2.66 g, 26 mmol) in DCM (60 mL) at 0C. The reaction was stirred at 0C for 3 hours, diluted with water (50 mL) and extracted into EtOAc (2 x 80 mL). The organic layers were combined, washed with brine, dried over sodium sulphate and concen- trated in vacuo. The solid was triturated with TBME to afford the title compound (2 g, 49% over 2 steps) as a brown solid that was used directly in the next step.
The synthetic route of 875781-43-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; THORARENSEN, Atli; BROWN, Matthew Frank; CASIMIRO-GARCIA, Agustin; CHE, Ye; FLANAGAN, Mark Edward; GILBERT, Adam Matthew; HAYWARD, Matthew Merrill; TELLIEZ, Jean-Baptiste; UNWALLA, Rayomand Jal; TRUJILLO, John I.; LIANG, Sidney Xi; (212 pag.)WO2016/178110; (2016); A1;,
Pyrazine – Wikipedia,
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