According to the analysis of related databases, 33332-25-1, the application of this compound in the production field has become more and more popular.
Reference of 33332-25-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33332-25-1 as follows.
EXAMPLE 43A. [00211] A solution of methyl 3-hydroxy-5-isopropoxybenzoate (Bioorg. Med. Chem. Lett., 15:2103 (2005)) (609 mg, 2.90 mmol), methyl 5-chloropyrazine-2- carboxylate (500 mg, 2.90 mmol), and K2CO3 (1.20 mg, 8.69 mmol) in CH3CN (20 mL) was heated to 8O0C for 2 h under an atmosphere of Ar (g). The reaction was cooled to RT, diluted with CH2Cl2 (50 mL) and filtered. The filtrate was concentrated in vacuo, and the residue was chromatographed (SiO2; 40 g; continuous gradient from 100% hexane to 100% EtOAc over 40 min) to provide Part A compound (1.005 g, 100% yield) as a colorless oil. [M + H]+ = 347.
According to the analysis of related databases, 33332-25-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/154563; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem