Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 68774-77-6, name is 8-Chloro[1,2,4]triazolo[4,3-a]pyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 68774-77-6
Add p-aminophenol (0.78 g, 7.2 mmol) and potassium tert-butoxide (1.46 g, 13.0 mmol) to the flask, use tetrahydrofuran as a solvent, and stir under an ice bath for 1 h under the protection of nitrogen; intermediate c (1 g, 6.5 mmol) and potassium iodide (0.12 g, 0.72 mmol) were added to the flask, tetrahydrofuran was used as a solvent, and the temperature was raised to 80 C., and the p-aminophenol after the reaction was added thereto, and reacted under the protection of nitrogen. After the reaction is completed, suction filtration is performed. The filtrate is spin-evaporated. After evaporation to dryness, a small amount of NaOH aqueous solution is added to sonicate, solids are precipitated, suction-filtered, and the filter cake is dried to obtain 0.45 g of a gray solid with a yield of 30.6%.
The synthetic route of 68774-77-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Xu Shan; Liu Xiaobo; Zhang Qian; Zhou Lingjia; Han Haoyun; Yu Li; Zhou Hualan; Qiu Yufeng; (25 pag.)CN110467616; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem