Synthetic Route of 75907-74-3, These common heterocyclic compound, 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step (1): to a 50 ml three-necked flask, the QR01006-IN-01 (500 mg, 3.29 mmol), dichloromethane (10 mL), chloromethyl chloroformate (460 mg, 3.6 mmol) were added. The resultant mixture solution was controlled at the temperature of -2 C., and then pyridine (0.32 mL) was dropwise added while controlling the temperature of no greater than 3 C. After the dropwise addition, the reaction solution was heated to room temperature and stirred overnight. The TLC (petroleum ether/ethyl acetate=1:3) was used to monitor the reaction until the raw materials were fully reacted. The reaction solution was filtered, and the resulting filtrate was dried by rotary evaporation, to give 1.1 g of yellow oil. The yellow oil was purified by preparative plate to give 620 mg of yellow liquid, with the yield of 77.3%. LCMS and HNMR spectra can confirm the structure of the target compound.
Statistics shows that (3,5,6-Trimethylpyrazin-2-yl)methanol is playing an increasingly important role. we look forward to future research findings about 75907-74-3.
Reference:
Patent; WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD; WUHAN QR PHARMACEUTICALS CO., LTD; GE, Jian; MA, Jianyi; XIANG, Guangya; WANG, Wei; WANG, Chaodong; (46 pag.)US2017/22188; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem