Synthetic Route of 36070-80-1, The chemical industry reduces the impact on the environment during synthesis 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, I believe this compound will play a more active role in future production and life.
A solution of (R)-tert-butyl 2-methylpiperazine-l-carboxylate (0.5 g, 2.5 mmol), 5-chloropyrazine-2- carboxylic acid (0.4 g, 2.5 mmol), HATU (1.14 g, 3 mmol) and triethylamine (0.64 g, 6.4 mmol) in dichloromethane (5 ml) was stirred at room temperature for 2 hours. To the mixture was added water (30 mL) and the organics were extracted with dichloromethane (20 mL). The organic layer was dried over Na2S04 and concentrated to dryness, and the residue was purified by silica gel flash column chromatography, eluting with ethyl acetate: petroleum ether = 1:5 to afford the title compound (780 mg, 2.29 mmol, 92 % yield). LCMS Method D RT= 1.54 min, ES+ve 241 [M-Boc+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CASILLAS, Linda N.; HARLING, John David; MIAH, Afjal Hussain; SMITH, Ian Edward David; RACKHAM, Mark David; (204 pag.)WO2017/182418; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem