Related Products of 313339-92-3, These common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of morpholine (12.5 mg, 0.144 mmol) and DIPEA (27.9 mg, 0.216 mmol) in 1 ml of dry THF was added two portion of 3,5-dichloropyrazine-2-carbonitrile (24.9 mg, 0.144 mmol). The reaction was stirred for 2 hours at rt. The solvent was removed under reduced pressure and the residue was suspended in ethyl acetate. The organic layer was washed with a 1M HC1 solution, a saturated aqueous solution of sodium bicarbonate and brine. The organic phase was dried over Na2S04 and concentrated in vacuo. The crude product was used in the next step without any further purification.
Statistics shows that 3,5-Dichloropyrazine-2-carbonitrile is playing an increasingly important role. we look forward to future research findings about 313339-92-3.
Reference:
Patent; RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA; GRAZIANI, Davide; MENEGON, Sergio; ANGELICO, Patrizia; RIVA, Carlo; (0 pag.)WO2020/11921; (2020); A1;,
Pyrazine – Wikipedia,
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