Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, A new synthetic method of this compound is introduced below., name: 5-Bromo-3-morpholinopyrazin-2-amine
A mixture of Intermediate 1-02 (8.17 g, 31.52 mmol) and 1,3-dichloroacetone (6.0 g, 47.29 mmol) in 2-propanol (15 mE) was heated in a sealed tube at 55 C. for 2 days. Oncooling, the mixture was filtered and rinsed with Et20 and MeOR. The solid was purified by flash chromatography on silica gel (MeOH:DCM, 5:95) and the product obtained was washed with MeOR and dried to give Intermediate 1-57(3.97 g, 38%).
The synthetic route of 117719-17-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); Serrano Marugan, Manuel; Pastor Fernandez, Joaquin; Martinez Gonzalez, Sonia; Ortega Molina, Ana; Bischoff, James R.; Oyarzabal Santamarina, Julen; (220 pag.)US9993554; (2018); B2;,
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