In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13134-31-1, name is 2,3-Diaminopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Product Details of 13134-31-1
EXAMPLE 2 2-(2-Methoxy-4-benzyloxy-phenyl)-imidazo[4,5-b]pyrazine A mixture of 2.2 g of 2,3-diaminopyrazine and 5.16 g of 2-methoxy-4-benzyloxy-benzoic acid was finely triturated in a mortar and then suspended in 80 ml of phosphorus oxychloride. The suspension was refluxed for 1.5 hours while stirring. After cooling, the reaction mixture was mixed with ice water. The solution thus obtained was neutralized with ammonia and extracted with ethyl acetate. The ethyl acetate phases were evaporated, and the residue was triturated with acetone, whereupon the reaction product was left behind in pure form. A second fraction was obtained by evaporating the acetone phase and purifying the residue on silica gel (eluant: methylene chloride/ethanol =100:0 to 100:4). Yield: 3.2 g (48% of theory). M.p. 178-180 C.
The synthetic route of 13134-31-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dr. Karl Thomae GmbH; US4656171; (1987); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem