Adding a certain compound to certain chemical reactions, such as: 88625-24-5, name is 5-Chloropyrazine-2-carbaldehyde, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 88625-24-5, Product Details of 88625-24-5
2,2,2-Trif[uoro-N-methy[ethanamine [CAS RN: 2730-67-8] (254 mg, 2.25 mmo[,1.6 eq), 5-ch[oropyrazine-2-carba[dehyde [CAS RN: 88625-24-5] (200 mg,1 .40 mmo[, 1 .0 eq) and sodium triacetoxyborohydride (952 mg, 4.49 mmo[,3.2 eq) were suspended in 20 mL 1,2-dichioroethane. Then, triethylamine (0.39mL, 2.81 mmo[, 2.0 eq) was added and the reaction mixture was stirred at rt overnight. Then, water was added. After stirring for 10 mm, the resulting phases were separated by the use of a Whatman filter. The volatile components of the organic phase were removed in vacuo and the crude material was purified via preparative MPLC (Biotage Isolera; 25 g SNAP cartridge: hexane/ethyl acetate9/1 -> hexane/ethyl acetate 1/1) to give 100 mg (29% yield of theory) of the title compound.UPLC-MS (Method 1): R = 1.13 mm; MS (EI0): m/z = 240 [M+H].1H-NMR (400 MHz, DMSO-d6): oe [ppm] = 2.39 (5, 3H), 3.37 (q, 2H), 3.92 (5, 2H),8.50 (d, 1H), 8.74 (d, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem