In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 912773-21-8, name is 2-Bromo-5-chloropyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 912773-21-8
To a suspension of copper (0) powder (244 g, 3880 mmol) in DMSO (5 L) was added ethyl 2-bromo-2,2-difluoroacetate (394 g, 1940 mmol) at room temperature. The reaction mixture was stirred at room temperature for 1 hour and 2-bromo-5-chloropyrazine (Shanghai Fchemicals Technology Co., Ltd., Shanghai, China) (250 g, 1290 mmol) was added in portion-wise manner. The reaction mixture was stirred at room temperature for 3 hours, then quenched with sat’d solution of ammonium chloride (2.0 L). The mixture was filtered through a celite pad and the filtrate was extracted with ethyl acetate (2 x 2 L). The combined organic layers were dried over Na2S04 and concentrated under reduced pressure. The residue was purified via silica gel chromatography (0 to 2% ethyl acetate in hexanes) to afford 4a (215 g, 70% yield) as a viscous colorless liquid. NMR (400 MHz, DMSO-t/6) delta 9.05 (d, J = 1.4 Hz, 1H), 8.98 (dd, J= 1.4, 0.7 Hz, 1H), 4.39 – 4.34 (m, 2H), 1.24 (t, J= 7.1 Hz, 3H).
The synthetic route of 912773-21-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; BOURBEAU, Matthew P.; CHEN, Ning; FROHN, Michael J.; HARRINGTON, Paul E.; LIU, Qingyian; REEVES, Corey; (108 pag.)WO2018/112081; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem