In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 951626-95-2 as follows. 951626-95-2
To the solution of piperidine (25 mg, 0.29 mmol) in dry THF (5 mL) was added trimethylaluminium (0.14mL, 0.29 mmol) drop wise at -10C under nitrogen over a period of 10 min. This solution was allowed to stir at room temperature for 45 minutes. Further the reaction mixture was re-cooled to -10C and thereto was added a solution of compound 5a (50 mg, 0.22 mmol) in THF (2.5 mL) drop wise. The resulting reaction mixture was stirred at room temperature initially then refluxed for 18 h. Reaction mixture was cooled to room temperature and quenched with iso-propanol (IPA) followed by methanol and then with saturated Na2SO4 solution. The reaction mixture was filtered and the filtrate was evaporated to dryness. The crude material was purified by column chromatography on silica gel (100-200 mesh) using MeOH in DCM to give desired compound 6a (50 mg, 85%). MS (ES+) m/z: 249. 1H NMR (400 MHz, CDCl3) delta 7.13 (s, 1H), 6.14-6.28 (m, 1H), 4.43 (m, 2H), 3.77-3.85 (m, 2H), 3.68-3.74 (m, 4H), 1.51-1.76 (m, 6H)
According to the analysis of related databases, 951626-95-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Surase, Yogesh B.; Samby, Kirandeep; Amale, Sagar R.; Sood, Ruchi; Purnapatre, Kedar P.; Pareek, Pawan K.; Das, Biswajit; Nanda, Kamna; Kumar, Subodh; Verma, Ashwani K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3454 – 3459;,
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