Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22047-25-2, name is Acetylpyrazine, A new synthetic method of this compound is introduced below., Formula: C6H6N2O
To a suspension of palladium (II) acetate (59 mg, 0.26 mmol), XANTPHOS (76 mg, 0.13 mmol) and tripotassium phosphate (3.9 g, 18 mmol) in dioxane (10 mL)/THF (2.7 mL)/toluene (2.7 mL) was added 1-(pyrazin-2-yl)ethanone (1.6 g, 13 mmol) and 1-bromo-2- fluorobenzene (0.72 mL, 6.6 mmol). The reaction mixture was degassed with nitrogen, sealed, and heated to 100 C for 18 hours, after which it was filtered through Celite and washed with several volumes of EtOAc. The filtrate was concentrated to a residue which was purified using silica gel chromatography utilizing a gradient of 1 to 10% methanol in dichloromethane to afford 2-(2-fluorophenyl)-1-(pyrazin-2-yl)ethanone (250 mg, 17 % yield) as an orange solid.1H NMR (500 MHz, methanol-d4) (ppm) 9.19 (s, 1 H), 8.85 (d, 1 H), 8.80 (m, 1 H), 7.31 – 7.34 (m, 2 H), 7.15 – 7.18 (m, 1 H), 7.09 – 7.13 (m, 1 H), 4.62 (s, 2 H).
The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IRONWOOD PHARMACEUTICALS, INC.; RENNIE, Glen, Robert; BARDEN, Timothy, Claude; LEE, Thomas, Wai-Ho; IYENGAR, Rajesh, R.; NAKAI, Takashi; MERMERIAN, Ara; JIA, James; IYER, Karthik; IM, G-Yoon, Jamie; RENHOWE, Paul, Allan; JUNG, Joon; GERMANO, Peter; TANG, Kim; (240 pag.)WO2018/89330; (2018); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem