4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H2N2O3
A solution of (S)-[1-(trans-4-amino-cyclohexyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-carbamic acid tert-butyl ester (176 mg, 0.5 mmol) and 2,3-pyrazinecarboxylic anhydride (75 mg, 0.5 mmol) in THF (5 mL) was stirred at reflux for 2 hours. The mixture was concentrated to dryness, treated with acetic anhydride (4 mL) and heated to reflux for 3 hours. The excess acetic anhydride was removed under high vacuum and the residue was partitioned between ethyl acetate and water. The aqueous layer was extracted with ethyl acetate and the combined organic phases were washed with water (3×) and brine, dried over magnesium sulfate and concentrated to dryness. The residue was triturated with ether and the light brown solid was isolated. This solid was dissolved in 4 N hydrogen chloride/dioxane (1 mL) and the solution was stirred at room temperature for 1 hour. Ether (2 mL) was added and the precipitate was collected and dried (17 mg, 8.6%). MS m/z 358 (MH+).
The synthetic route of 4744-50-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pfizer Inc; US2005/234065; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem