The chemical industry reduces the impact on the environment during synthesis 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, I believe this compound will play a more active role in future production and life. 87486-34-8
A flask equipped with a magnetic stirrer was charged with l-(2-(tert- butyldimethylsilyloxy)ethyl)-lH-pyrazol-4-amine 116b (1. 7 g, 7.1 mmol), 3,5-dibromo-l- methylpyrazin-2(lH)-one (1.25 g, 4.7 mmol), and IPA (25 rriL). The system was evacuated and then refilled with N2. The reaction mixture was heated at 90¡ãC for 6 h. Then, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by flash column chromatography eluting with petroleum ether/ethyl acetate to afford 140a (1.7 g, 78percent). LCMS: [M+H]+ 314.
The chemical industry reduces the impact on the environment during synthesis 87486-34-8. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GILEAD CONNECTICUT, INC.; GENENTECH, INC.; BARBOSA, Antonio, J., M.; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KRISHNAMOORTHY, Ravi; KROPF, Jeffrey, E.; LEE, Seung H.; MITCHELL, Scott A.; ORTWINE, Daniel; SCHMITT, Aaron, C.; WANG, Xiaojing; XU, Jianjun; YOUNG, Wendy; ZHANG, Honglu; ZHAO, Zhongdong; ZHICHKIN, Pavel E.; WO2011/140488; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem