Related Products of 56423-63-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56423-63-3 as follows.
Ethyl 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-l-{2-[4-(trifluoromethoxy)phenoxy]ethyl}- lH-indole-2-carboxylate (34 mg, 0.065 mmol), 2-bromoprazine (21 mg, 0.13 mmol), K2C03 (27 mg, 0.2 mmol) and S Phos (2.7 mg, 0.006 mmol) were combined in 1.0 mL of dioxane in a flask. The reaction was degassed and filled with nitrogen. Water (0.2 mL) was added and purged again with nitrogen. Palladium acetate (0.7 mg, 0.003 mmol) was added, and the reaction was heated to 90C overnight. EtOAc was added and the crude mixture was filtered through a pad of Celite. The volatiles were concentrated in vacuo, and the reaction was purified on reverse phase HPLC (25-55% ACN in H20 (w/ 0.1% TFA)) to yield the title product. HRMS: Calc forC22H17F3N304 444.1171. Found 444.1 167
According to the analysis of related databases, 56423-63-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; HANNEY, Barbara; MANLEY, Peter; RUDD, Michael, T.; SANDERS, John, M.; STACHEL, Shawn, J.; HENZE, Darrell; WO2013/9582; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem