Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, A new synthetic method of this compound is introduced below., Safety of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
15 g (45 mmol) of the compound (2) (R) -3- (tert-butoxycarbonylamino) -4- (2,4,5-trifluorophenyl) butyric acid,Compound (3) 3- (Trifluoromethyl) -5,6,7,8-tetrahydro- [1,2,4] triazolo [4,3-a] pyrazine hydrochloride 11.3 g(49.5mmo 1),HOBT 7.3 g (54 mmol) was added to 150 ml of dichloromethane.At room temperature,14.4 g (135 mmol) of 2,6-dimethylpyridine was added,Then add 10.3 g (54 mmol) of EDC-HC1,The mixture was stirred at room temperature for 3 hours.Add 5% sodium carbonate aqueous solution to adjust rhoH- = 9,Layered,The methylene chloride layer was washed with 150 ml of water,Layered,The methylene chloride layer was dried over anhydrous sodium sulfate,filter,The filtrate was evaporated at 35 C under reduced pressure to give 21.7 g of the compound (1)Yield 95%HPLC 94.5%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zhejiang Huahai Pharmaceutical Co., Ltd; GE, JIANFENG; YAN, FENGFENG; (6 pag.)CN102603749; (2017); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem