Electric Literature of 622392-04-5,Some common heterocyclic compound, 622392-04-5, name is 2-Bromo-5-iodopyrazine, molecular formula is C4H2BrIN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(l-((l-(Trifluoromethyl)cyclobutyl)methyl)piperidin-4-yl)methanol (0.88 g, 3.50 mmol) was dissolved in THF (30 mL). At 0C, NaH (0.13 g, 5.25 mmol) was added thereto. The mixture was stirred for 30 minutes. 2-bromo-5-iodopyrazine (1.09 g, 3.85 mmol) was added thereto, followed by stirring at 55C for 10 h. To the reaction mixture, water was added, and the mixture was extracted with EtOAc. The organic layer was washed with saturated brine aqueous solution, dried with anhydrous MgS04, and then concentrated under reduced pressure. The obtained product was used without further purification. (1.40 g, 87%, colorless oil).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-5-iodopyrazine, its application will become more common.
Reference:
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; KIM, Yuntae; LEE, ChangSik; CHOI, DaeKyu; KO, MooSung; HAN, Younghue; KIM, SoYoung; MIN, JaeKi; KIM, DoHoon; WO2015/80446; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem