117719-17-2, The chemical industry reduces the impact on the environment during synthesis 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, I believe this compound will play a more active role in future production and life.
To a solution of Intermediate 1-02 (3 g, 9.288 mmol) in 2-propanol (46 mL), 2- chloro-3-oxo-succinic acid diethyl ester (6.2 g, 27.865 mmol) was added. The reaction mixture was heated in a Parr reaction vessel at 90 C for 2 days. The solvent was evaporated and the residue was purified by automated column chromatography (Biotage, EtOAc:Cyclohexane, 0: 100 to 40:60). The product obtained was treated with Et20 and filtered to give the expected product 1-39 (1.2 g, 34 %) as a white solid.
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-3-morpholinopyrazin-2-amine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONC&Oacgr;LOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; ALVAREZ ESCOBAR, Rosa Maria; RODRIGUEZ ARISTEGUI, Sonsoles; GONZALES CANTALAPIEDRA, Esther; HERNANDEZ HIGUERAS, Ana Isabel; VARELA BUSTO, Carmen; WO2011/36461; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem