In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4430-75-5 as follows. Product Details of 4430-75-5
8. Synthesis of 2-(1-(triisopropylsityl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine Into a 100 mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen was placed 6-bromo-1-(triisopropylsilyl)-1H-indole (2 g, 5.40 mmol). To this was added octahydro-1H-pyrido[1,2-a]pyrazine (2.1 g, 14.25 mmol). Addition of t-BuONa (2 g, 20.83 mmol) was next. This was followed by the addition of (t-Bu)3P (200 mg, 0.99 mmol). This was followed by the addition of Pd(OAc)2 (50 mg, 0.22 mmol). To the mixture was added xylene (30 mL). The resulting solution was allowed to react, with stirring, for 2 hours while the temperature was maintained at 110 C. in a bath of oil. The reaction progress was monitored by TLC (CH2Cl2MeOH=10:1). The resulting mixture was washed 1 time with 30 mL of H2O. The resulting solution was extracted three times with 100 mL of ethyl acetate and the organic layers combined. The resulting mixture was washed 1 time with 10 mL of NaCl(sat.). The mixture was dried over Na2SO4 and concentrated by evaporation under vacuum using a rotary evaporator. This resulted in 2.15 g (80%) of 2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine as red oil.
According to the analysis of related databases, 4430-75-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; US2008/200471; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem