875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: Pyrazines
2-bromo-5H- pyrrolo [2,3-b] pyrazine (5.0g, 25.2 mmol) of 1,4-dioxane (100mL) 2.0M NaOH aqueous solution to the partial suspension in (25mL, 50 2.0 mmol) and 37% formaldehyde aqueous solution (19mL, 252 mmol) was added. The reaction mixture of this dark homogeneous mixture was stirred overnight at room temperature. The organics were evaporated under reduced pressure. The aqueous layer was neutralized with 1.0 M HCl, and extracted with EtOAc (2x). And the combined organics concentrated to give a solid orange 2.6 g. When allowed to stand, thick brown precipitate formed in the aqueous layer. This precipitate was collected by filtration, and dried. And extracted with the hot brown solid 10% MeOH / EtOAC (3x200mL). The extracts are combined and evaporated to give an additional solid orange 3.05 g. The entire yield, 5.65g (87%) (2-bromo-7-hydroxymethyl-pyrrolo [2,3-b] pyrazin-5-yl)-methanol.
The synthetic route of 875781-43-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F.HOFFMANN-LA ROCHE AG; HENDRICKS, ROBERT THAN; HERMANN, JOHANNES CORNELIUS; KONDRU, RAMA K; LOU, YAN; LYNCH, STEPHEN M; OWENS, TIMOTHY D; SOTH, MICHAEL; (50 pag.)JP5667692; (2015); B2;,
Pyrazine – Wikipedia,
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