50866-30-3, Name is 5-Methylpyrazine-2-carbaldehyde, 50866-30-3, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
The compound (82.2 mg) obtained in Example 47-3 was dissolved in methanol (5.0 ml) and added with the compound (35.9 mg) obtained in Example 73-1, followed by the addition of sodium cyanoborohydride (36.9 mg). Then, the reaction solution was adjusted to about pH 5 with acetic acid, followed by stirring at room temperature for 16 hours. The reaction solution was added with a saturated aqueous sodium bicarbonate solution and then extracted with chloroform. The organic layer was washed with saturated saline solution and then dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off. The resulting crude product was purified through silica gel column chromatography (chloroform/methanol) and treated with hydrochloric acid, thereby obtaining hydrochloride (84.0 mg) of the subject compound as a pale-yellow solid. MS(FAB,Pos.):m/z=526[M+H]+1H-NMR(500MHz,DMSO-d6):delta=0.87(6H,t,J=7.3Hz),1.69-1.78(4H,m),2.47(3H,s),2.86-2.95(4H,m),3.82(2H,s),3.85(2H,s),4.11(2H,s),4.26(2H,d,J=5.2H z),7.58-7.62(6H,m),7.88-7.89(2H,d,J=8.7Hz),7.95-7.96(2H,d,J=8.4Hz),8.47(1H,dd,J=0.6,1.3Hz),8.69(1H,d,J=1.4Hz ),10.47(1H,s),10.70(1H,brs),14.51(1H,brs).
Statistics shows that 5-Methylpyrazine-2-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 50866-30-3.
Reference:
Patent; Kureha Chemical Industry Co., Ltd.; EP1550657; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem