109-08-0,Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 5 N-((3RS)-1-tert-Butylcarbonylmethyl-2,3-dihydro-2-oxo-5-(2-pyrazinyl)-1H-1,4-benzodiazepin-3-yl)-N’-(3-methylphenyl)urea (Compound 17) STR16 5A Phenacyl pyrazine Phenacyl pyrazine was prepared from methyl pyrazine and methyl benzoate as described by Behun and Levine (J Am Chem Soc 1959, 81, 5157) in 68% isolated yield (chromatography on silica-eluant 60% EtOAc in hexanes).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methylpyrazine, its application will become more common.
Reference:
Patent; Ferring-Research Limited; Yamanouchi Pharmaceutical Co. Ltd.; US5728829; (1998); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem