Synthetic Route of 762240-92-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.
589 mg (1 mmol) of the compound of the formula (2-1), 457 mg (2 mmol) of the compound of the formula (3) and 3 mL of triethylamine were dissolved in 10 mL of dichloroethane, and the mixture was stirred at 70C for 48 hours. Then, the mixture was extracted with water and dichloromethane, and then the organic solvent was collected and water was removed in the presence of sodium sulfate (Na2SO4). The filtrate obtained through the Celite filter was removed under reduced pressure, and the first citric acid complex intermediate of formula (1-1) was obtained in a yield of 91% by column chromatography.
The chemical industry reduces the impact on the environment during synthesis 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sungkyunkwan University Industry-Academic Cooperation Foundation; Song, Chung Uii; Bae, Han Yong; (22 pag.)KR2017/93021; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem