Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1196152-38-1, name is 2-Bromo-5-(trifluoromethyl)pyrazine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1196152-38-1
bis(triphenylphosphine)palladium(II) chloride (21.40 mg, 0.030 mmol), triphenylphosphine (15.99 mg, 0.061 mmol), TEA (4.5 ml, 32.3 mmol), 2-bromo-5-(trifluoromethyl)pyrazine (346 mg, 1.524 mmol) and copper(I) iodide (11.61 mg, 0.061 mmol) were collected together in a round bottomed flask. The mixture was stirred for 30 minutes and then 1,1- dimethylethyl (lR,4S,6R)-4-ethynyl-3-azabicyclo[4.1.0]heptane-3-carboxylate D5 (337 mg) was added. The reaction was stirred at room temperature for 2 hours.A saturated solution of H4CI (10 ml) was added and the aqueous layer was back extracted with diethyl ether (3 x 10 ml). The collected organic layers were washed with brine (3 x 5 ml), dried over Na2S04, filtered, and concentrated under vacuum to give the crude product. The crude product was purified by silica gel chromatography (SNAP KP-Sil 25g cartridge; eluted with Cy/EtOAc 5CV from 100% Cy to 90/10, 5 CV 90/10).Collection and evaporation of the fractions gave the title compound D27 (300 mg).UPLC (GEN_QC_SS) rt = 1.02 minutes, peak observed: 312 [M-C(CH3)3] Ci8H20F3N3O2 requires: 368.
According to the analysis of related databases, 1196152-38-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; DI FABIO, Romano; WO2012/89607; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem