Synthetic Route of 56423-63-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56423-63-3, name is 2-Bromopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
mixture of 3,3′,3″-(l,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(N-(4- (trifluoromethoxy)phenyl)benzamide) (Stage 5.1, 65 mg, 0.071 mmol), 2-bromopyrazine (63.6 mg, 0.4 mmol), Pd(PPh3)2Cl2 (8.42 mg, 0.012 mmol), Na2C03 (63.6 mg, 0.600 mmol), DME (299 muGamma), water (86 muGamma), and EtOH (42.8 mu) was stirred at 80C for 16 h. The RM was cooled, diluted with THF (4 mL), stirred for 2 h with Si-Thiol (Silicycle, 118 mg, 0.150 mmol), filtered and the filtrate was evaporated off under reduced pressure to give the crude product which was purified by flash chromatography (Redisep Silica gel column, 12 g, cyclohexane / EtOAc, from 20% to 75% EtOAc) to afford the title compound as white needles. UPLC-MS (Condition 1) tR = 2.66 min, m/z =360.0 [M+H]+, m/z =358.0 [M-H]”; XH-NMR (400 MHz, DMSO-d6) delta ppm 7.40 (d, J=8.6 Hz, 2 H) 7.67 – 7.77 (m, 1 H) 7.92 (d, J=9.0 Hz, 2 H) 8.08 (d, J=7.8 Hz, 1 H) 8.37 (d, J=7.8 Hz, 1 H) 8.67 – 8.71 (m, 2 H) 8.77 – 8.80 (m, 1 H) 9.38 (d, J=1.5 Hz, 1 H) 10.59 (s, 1 H).
The synthetic route of 2-Bromopyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; FURET, Pascal; GROTZFELD, Robert Martin; JONES, Darryl Brynley; MANLEY, Paul; MARZINZIK, Andreas; MOUSSAOUI, Saliha; PELLE, Xavier Francois Andre; SALEM, Bahaa; SCHOEPFER, Joseph; WO2013/171641; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem