In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 762240-92-6 as follows. name: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
At room temperature, compound I22.8g (100mmol), bromoacetyl chloride 31.2g (200mmol) and cesium carbonate 65.2g (200mmol) were added to the flask in 100mL DMF and stirred for 3h at room temperature; after the reaction was completed, ethyl acetate was extracted The organic phase was concentrated, washed with water, and then recrystallized from ethanol, and dried to obtain 28.4 g of compound II in a yield of 91%.
According to the analysis of related databases, 762240-92-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nanjing Qike Pharmaceutical Co., Ltd.; Yang Bo; Chen Yao; (11 pag.)CN110577542; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem