356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 356783-16-9
A mixture of 8 (2.6 g, 15.0 mmol), KF (5.23 g, 90.0 mmol), tetrabutylammonium bromide (1.93 g, 6.0 mmol) was predried under vacuum over phosphorus pentoxide. The mixture was charged in a polytetrafluoroethylene bottle followedby the addition of dried DMSO (20 mL), and heated at 60 C for 2.5-3 h. The reaction mixture was cooled to room temperature, treated with water (80 mL) and extracted with diethyl ether (100 mL). The organic layer was washed with water (3 ¡Á 25 mL), dried over Na2SO4, and purified by chromatography on silica gel with PE/EA (50:1-10:1) as eluent to give 9 as a white solid (1.27 g, yield 60%). 3,6-Difluoropyrazine-2-carbonitrile (9) Yield: 60%. white solid, M.p.: 58-60 C (Lit. 56-57 C, Li 2017). 1H NMR (400 MHz, CDCl3)delta 8.35 (dd, J = 8.1,1.4 Hz, 1H). 13C NMR (125 MHz, CDCl3):delta 159.73-157.69(d, J = 255 Hz), 157.64-155.62 (d, J = 252.5 Hz), 135.09 (dd, J = 41.6, 11.0 Hz), 114.04 (d, J = 35.8 Hz), 110.62 (d,J = 9.1 Hz). EI-MS m/z: 141 (M+, 100), 122 (M+, -F, 50),96 (M+, -F, -CN, 50).
Statistics shows that 356783-16-9 is playing an increasingly important role. we look forward to future research findings about 3,6-Dichloropyrazine-2-carbonitrile.
Reference:
Article; Guo, Qi; Xu, Mingshuo; Guo, Shuang; Zhu, Fuqiang; Xie, Yuanchao; Shen, Jingshan; Chemical Papers; vol. 73; 5; (2019); p. 1043 – 1051;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem