875781-43-4, A common heterocyclic compound, 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-bromo-7-iodo-5H-pyrrolof3,2-blpyrazine CIV-E-I); A mixture of III-E-1 (5.0 g, 25 mmol; commercially available from Ark pharma) and freshly ground KOH (5.10 g, 90.9 mmol) in DMF (100 mL) was stirred at RT under N2 for 30 min. Iodine (6.35 g, 25.02 mmol) was then added in one portion and the red mixture was stirred at RT for 2 h when TLC indicated that the reaction was complete. The mixture was poured into water (100 mL) and extracted with EtOAc (3 x 100 mL). The combined organic extracts were dried and concentrated to give IV-E-I (7.74 g, 95%) as a brown solid. 1H NMR (400 MHz, CDCl3) delta 7.67 (s, IH), 8.23 (s, IH).
The synthetic route of 2-Bromo-5H-pyrrolo[2,3-b]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EISAI R & D MANAGEMENT CO. LTD; GRACZYK, Piotr; BHATIA, Gurpreet, Singh; WO2010/15803; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem