Reference of 109-08-0, These common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A 2.5 M hexanes solution of n-BuLi (18.0 mL, 45 mmol) was added to a -78 °C THF solution (60 mL) of ^-BuOK (5.1 g, 45 mmol) and diisopropylamine (6.3 mL, 45 mmol). After 5 min at -78 °C the yellow mixture was warmed to -40 °C. Neat methylpyrazine (2.7 mL, 30 mmol) was added and the mixture rapidly turned dark red. After 30 min at -40 °C the mixture was cooled to -78 °C and neat allyl bromide (7.6 mL, 90 mmol) was added. After 30 min at -78 °C water was added and the mixture was partially concentrated to remove volatile organics. The resulting mixture was extracted with dichloromethane and the combined organics were dried (Na2SO4), concentrated, and purified via column chromatography to give 2.2 g of 2-but-3-enyl-pyrazine.
The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARBAY, J., Kent; LEONARD, Kristi; CHAKRAVARTY, Devraj; SHOOK, Brian, Christopher; WANG, Aihua; WO2010/45012; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem