873-40-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 873-40-5, name is 2,3,5-Trichloropyrazine, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Under nitrogen gas stream 2,3,5-trichloropyrazine of 28g (152.65mmol),2-chlorophenylboronic acid of 23.8g (152.65mmol),Put THF / H2O and K2CO3 of 800ml / 200ml 63.3g (457.9mmol) and stirred. At 40 into the Pd (PPh3) 4 of 5.3g (4.58mmol) was stirred at 80 for 12 hours.After completion of the reaction, which was then extracted with dichloromethane. The organic layer was dried over MgSO4 filtered under reduced pressure. The filtered organic layer was evaporated under reduced pressure to a back by column chromatography the desired compound 2,5-dichloro-3- (2-chlorophenyl) pyrazine 12g (yield: 30%) was obtained.
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Reference:
Patent; Doosan Corporation; Kim, Tae Hyung; Bae, Hyung Chan; Son, Hyo Suk; Baek, Young Mi; Patk, Ho Chul; (54 pag.)KR101488560; (2015); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem