In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41110-28-5, name is 3-Methylpyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3-Methylpyrazine-2-carboxylic acid
To a stirred solution of MeOH (50 mL) was added SOCl2(8.6 g, 72.4 mmol) dropwise at 0C. Then 3-methylpyrazine-2-carboxylic acid (5 g, 36.2 mmol) was added to the reaction. The mixture was stirred at 60 C overnight. The mixture was concentrated under reduced pressure and the residue was dissolved into EA (50mL) . The organic phase was washed with saturated aq.NaHCO3(50 mL) . The organic phase was washed with brine, dried over Na2SO4and concentrated under reduced pressure. The residue was purified by silica gel chromatography (eluted with: EA/PE = 1/1) to afford the title compound as yellow solid (3.9g, yield: 70.9%) . MS: M/e 153 (M+1)+.
The synthetic route of 41110-28-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BEIGENE, LTD.; ZHANG, Guoliang; SUN, Hanzi; ZHOU, Changyou; (253 pag.)WO2020/20097; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem