762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 762240-92-6
Azetidinone lla’ (0.5 g, 2.32 mmol, ee 99.5 %), 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1 ,2,4]triazolo[4,3-a] pyrazine hydrochloride (Ill’, 1.06 g, 4.65 mmol), Et3N (0.28 g, 4.65 mmol) and 2-ethylhexanoic acid (0.17 g, 1.16 mmol) were suspended in THF (1 0 ml). The resulting suspensionwas stirred at 75C for 72 h. After cooling the mixture to 0C, the excess of the compound Ill’ wasfiltered off and the solvent was removed in vacuo. To the remaining oil was added water (1 0 ml) andthe product was extracted with dichloromethane (3 x10 ml). The organic phases were combined,dried over magnesium sulfate and concentrated in vacuo to give 0.90 g of sitagliptin (IV”) (95%, ee99.5 %) as dark yellow oil.
The synthetic route of 762240-92-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LEK PHARMACEUTICALS D.D.; STARCEVIC, Stefan; MRAK, Peter; KOPITAR, Gregor; WO2013/186326; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem