Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 109838-85-9
A 1.6M n-butyllithium solution in hexane (100 ml) is added dropwise [AT-75°] C. to a solution of (2R) -2, 5-dihydro-2-isopropyl-3,6-dimethoxypyrazine (29.5 g) in absolute tetrahydrofuran (530 ml). The reaction mixture is then stirred [AT-75°] C. for 30 minutes, and then a solution of 2 [(S)- (BENZYLOXYMETHYL)-3-METHYL-BUTYL] bromide (29 g) in tetrahydrofuran (130 ml) is added over a period of 20 minutes. The reaction solution is stirred [AT-75°] C. for a further 2 hours and is then left to stand [AT-18°] C. for 64 hours. The reaction mixture is concentrated by evaporation, water (500 ml) is added, and extraction is carried out with diethyl ether [(3X500] ml). The organic phases are washed with saturated sodium chloride solution (500 ml), dried over magnesium sulfate and concentrated by evaporation. The evaporation residue is purified by FC (2.4 kg of silica gel, ethyl acetate-hexane 1: 15), and the title compound (36.2 g) is obtained in the form of a yellowish oil: Rf (B) =0.58. HPLC Rt =25.8 min.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109838-85-9.
Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2003/103652; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem