As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4858-85-9 name is 2,3-Dichloropyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 4858-85-9
2,3-Pyrazinedithiol (pdt) was synthesized according to a literature procedure [15,26-28]. 2,3-Dichloropyrazine (12.02g, 0.07668mol) was dissolved in 200mL MeOH under inert atmosphere. NaSH¡¤xH2O (23.49g, 0.2133mol) was dissolved in 100mL H2O under inert atmosphere. The solutions were combined, and the yellow reaction mixture was brought to reflux at 90C for 15h. 100mL of a 1.21M HCl (aq) solution was slowly added to the reaction mixture. The mixture slowly turned red, and some dark red precipitate was visible. The mixture was cooled to -20C for 3h, after which the precipitate (4.972g, 42.7%) was filtered and washed with cold MeOH. 1H NMR (CDCl3): 13.50ppm (2H), 6.85ppm (2H). IR (neat): nu/cm-1=3083, 2893, 1630, 1547, 1528, 1480, 1316, 1290, 1148, 1133, 1071, 1051, 852, 828, 820, 803, 726, 668, 623. Element. Anal. Calc. for H4C4N2S2: H, 2.80; C, 33.31; N, 19.42; S, 44.47. Found: H, 2.83; C, 32.92; N, 19.05; S, 44.23%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dichloropyrazine, and friends who are interested can also refer to it.
Reference:
Article; Kennedy, Steven R.; Kozar, Morgan N.; Yennawar, Hemant P.; Lear, Benjamin J.; Polyhedron; vol. 103; (2016); p. 100 – 104;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem