Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Chloropyrazine-2-carbonitrile
The starting compound 3-chloropyrazine-2-carbonitrile (35.8 mmol) was dispersed in a 10percentsolution of sodium hydroxide (125 mmol, 3.5 equiv.) in a round bottom flask. The reaction mixturewas stirred and heated under reflux in an oil bath for 7 h. The progress of the reaction was monitoredby TLC in the system butanol/acetic acid/water (4:1:5). The reaction mixture was acidified by 10percentsolution of hydrochloric acid to pH 3. Resulting crystals of 3-chloropyrazine-2-carboxylic acid weresuctioned. The melting point and 1H-NMR corresponded with the literature [17].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Semelkova, Lucia; Jand’ourek, Ond?ej; Kone?na, Klara; Paterova, Pavla; Navratilova, Lucie; Trejtnar, Franti?ek; Kubi?ek, Vladimir; Kune?, Ji?i; Dole?al, Martin; Zitko, Jan; McPhee, Derek J.; Molecules; vol. 22; 3; (2017);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem