Related Products of 72788-94-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 72788-94-4 as follows.
To a solution of (5-fluoro-2-methoxypyridin-4-yl) boronic acid (2.60 g, 15.2 mmol) and (5-chloropyrazin-2-yl) methanol (2.00 g, 13.8 mmol) in THF (10 mL) and water (2.0 mL) were added K3PO4 (8.80 g, 41.5 mmol) and PdCl2 (dppf) (1.01 g, 1.38 mmol) under a N2 atmosphere. The reaction mixture was stirred at reflux with a 100 bath for 2 hours. Then the reaction mixture was added to water (10 mL) and extracted with EtOAc (2.0 mL×3) . The combined organic layers were washed with brine (10 mL) , dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo to give a residue, which was purified by preparative TLC (PE/EtOAc 5: 1) to afford (5- (5-fluoro-2-methoxypyridin-4-yl) pyrazin-2-yl) methanol. MS (ESI) m/z: 236.0 [M+H] +.
According to the analysis of related databases, 72788-94-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CHOBANIAN, Harry; PLUMMER, Christopher W.; DEMONG, Duane; FANG, Minghai; HU, Bin; (122 pag.)WO2016/19863; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem