Some common heterocyclic compound, 87486-33-7, name is 3,5-Dichloro-1-methylpyrazin-2(1H)-one, molecular formula is C5H4Cl2N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3,5-Dichloro-1-methylpyrazin-2(1H)-one
EXAMPLE 2 3-Amino-5-chloro-1-methyl-2(1H)-pyrazinone A solution of 3,5-dichloro-1-methyl-2(1H)-pyrazinone (7.16 g, 0.040 mol) in dioxane (120 mL) was treated with a concentrated aqueous solution of ammonia (28%, 16 mL, 0.24 mol). After stirring at room temperature for three days a suspension of solid had formed. The solid was collected, rinsed with a little water, ether, and hexanes and air dried. The product, 3-amino-5-chloro-1-methyl-2(1H)-pyrazinone, was obtained as a white crystalline powder (4.81 g) melting above 250 C. PMR (DMSO-d6, 200 MHz): delta 7.16 (broad s, 2H, NH2); 6.99 (s, 1H, Het-H); 3.34 (s, 3H, N–CH3). IR (Nujol mull): 3310 (w, NH); 3170 (w, NH); 1660 (s, C=O) cm-1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 87486-33-7, its application will become more common.
Reference:
Patent; E. I. Du Pont de Nemours and Company; US4802908; (1989); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem