Related Products of 6905-47-1, A common heterocyclic compound, 6905-47-1, name is 2-Amino-6-methoxypyrazine, molecular formula is C5H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 6-methoxypyrazin-2-amine (0.5 g, 4.0 mmol) in CHCI3 (25 mL) was added NCS (533 mg, 4.0 mmol). The reaction mixture was stirred at 40C for 12 h. The mixture was concentrated to give a residue. The residue was purified by column chromatography (Si02) to give 5-chloro-6-methoxypyrazin-2-amine (95 mg, 14.9% yield) as a yellow solid. NMR (400MHz, CHLOROF ORM-f) delta 7.32 (s, 1H), 4.42 (s, 2H), 3.96 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; QUENTIS THERAPEUTICS, INC.; VACCA, Joseph P.; LI, Dansu; BETTIGOLE, Sarah; (214 pag.)WO2019/94641; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem