Adding some certain compound to certain chemical reactions, such as: 95-58-9, name is 2-Chloro-3-methylpyrazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 95-58-9. 95-58-9
Compound 1 (500 g, 1.92 mol) and aqueous ammonia (5.5 L) were placed in a 10 L autoclave and reacted at 160 C for 24 hours. TLC or LCMS showed the reaction was completed.The reaction was cooled and filtered to give a white solid, the remaining reaction solution was extracted with ethyl acetate (1.5 L x 5), the extracts were combined, dried over anhydrous sodium sulfate,The resulting white solid was concentrated under reduced pressure and combined with the filtered solid which was dried in vacuo to give crude compound 2 (420 g).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-Chloro-3-methylpyrazine.
Reference:
Patent; Shanghai He Quan Pharmaceutical Co., Ltd.; Shanghai He Quan Pharmaceutical Research And Development Co., Ltd.; Changzhou Hequan Pharmaceutical Co., Ltd.; Changzhou Hequan Drug Discovery Co., Ltd.; Wuxi Yaoming Kant, Immanuel Pharmaceutical Co., Ltd.; Wuxi Yaoming Kant, Immanuel Bio-technology Co., Ltd.; Mao Yanjun; Tang Xiaowu; Guo Zemin; He Mina; Jiang Xinxin; Bao Weize; Wu Dongping; Yuan Chaowei; Li Hong; Yu Lingbo; Ma Rujian; (5 pag.)CN107312007; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem