5049-61-6, name is Pyrazin-2-amine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C4H5N3
A mixture of pyrazin-2-amine (2) (1.0 equiv.) and ethyl 3-bromo-2-oxopropanoate (3) (1.5 equiv.) in ethanol (15 mL)was exposed to microwave irradiation at 200 W intermittently at 10 s intervals for 30 min at 150 C. On completion of reaction as indicated by TLC, the reaction mixture was cooled, concentrated and treated with cold water. Reaction mass was concentrated completely under reduced pressure. Obtained crude was purified by column chromatography on 100-200 silica gel by eluting 50 % ethyl acetate in n-hexane, to get off pale brown compound 4, yield: 90 %; m.p. 151-153 C. IR (KBr, numax, cm-1): 3352, 3081, 3009, 2959, 2918, 1748, 1612, 1426, 1426,1353, 1276, 1254, 903, 813; 1H NMR (400 MHz, DMSO-d6):delta 1.28 (t, 3H, CH3), 3.85 (q, 2H, CH2), 4.62 (brs, 1H, NH); LC-MS: m/z 192.06 [M+H] +. Anal. calcd. (%) for C9H9N3O2:C 56.54, H 4.74, N 21.98. Found (%): C 56.65, H 4.76, N22.03.
The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jyothi, Boggavarapu; Madhavi, Nannapaneni; Asian Journal of Chemistry; vol. 32; 1; (2020); p. 84 – 90;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem