Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33332-28-4, name is 2-Amino-6-chloropyrazine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Amino-6-chloropyrazine
To a mixture of compound 9 (312.0 g, 2A mol) and K2C03 (664.0 g, 4.8 mol) in MeCH(1.0 L) was dropwise added lCl (704.0 g, 4.3 mol in 1.0 L of DCM) over 2 hours0C. Then the reaction mixture was stirred at room temperature overnight. Thereaction was quenched with Na2SO3 aqueous solution (2M, 1 .5 L). The mixture was extracted with DCM (1.0 L x 3). The combined organic phases were dried over anhydrous Na2SO4, filtered and concentrated. The crude product was purifiedcolumn chromatography on silica gel (PEIEA = 10/1 to 4/1) to afford compound(460 g, 75% yield) as a solid.1HNMR (400 MHz, DMSQd6): 7.68 (s, 1H), 7.07 (s 2H). MS Calcd.: 255 MS Found: 256 ([M+Hfl.
According to the analysis of related databases, 33332-28-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; H. LUNDBECK A/S; SVENSTRUP, Niels; WEN, Kate; WANG, Yazhou; (78 pag.)WO2017/5786; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem