Application of 36070-75-4, The chemical industry reduces the impact on the environment during synthesis 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, I believe this compound will play a more active role in future production and life.
The rac-I -((2S,3R,4R)-4-amino-2-ethyl-6-fluoro-3-methyl-3,4-dihyd roquinolin- I (2H )-yl)ethanone (forpreparation see Intermediate 40, 100 mg, 0.400 mmol), 5-chloropyrazine-2-carbonitrile (III mg,0.799 mmol), DIPEA (0.140 mL, 0.799 mmol) and N-methyl-2-pyrrolidone (NMP) (2 mL) were placeda microwaveable vial and irradiated in a microwave at 200 C for 2.5 h. The reactions purified directly using a MDAP (Formic) to give a solid, this solid was eluted through a NH2 SPE (5 g) with MeOH, the eluent was concentrated and dried to give the product (77 mg, 0.218 mmol, 54.5%) as an orange solid. LCMS (2 mm Formic): Rt = 0.93 mi [MH] = 354.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AMANS, Dominique; ATKINSON, Stephen John; HARRISON, Lee Andrew; HIRST, David Jonathan; LAW, Robert Peter; LINDON, Matthew; PRESTON, Alexander; SEAL, Jonathan Thomas; WELLAWAY, Christopher Roland; WO2014/140076; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem