Electric Literature of 54608-52-5,Some common heterocyclic compound, 54608-52-5, name is 2-Hydrazinopyrazine, molecular formula is C4H6N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 15.0 g (136 mmol) of 2-hydrazinopyrazine in 100 ML of trimethyl orthoformate was heated to reflux at 100 C for 1.5 h. The solvent was removed in vacuo and the crude product was applied to a pad of silica gel and eluted with 15: 85 methanol : ethyl acetate. The resulting solution was concentrated in vacuo to yield the title compound. LC/MS 121.0 (M+1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Hydrazinopyrazine, its application will become more common.
Reference:
Patent; MERCK & CO., INC.; WO2004/58266; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem