Adding a certain compound to certain chemical reactions, such as: 91775-62-1, name is 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 91775-62-1, Product Details of 91775-62-1
To a well stined solution of silver(I)fluoride (3.4g, 26.5 mmol) in DMF (20 ml), wasadded trifluoromethyltrimethylsilane and stined at room temperature for 0.5h. To the reactionmixture, was added copper (2.4g, 39.0 mmol) and stined at room temperature for 4h. Then added 3-bromo-8-methoxyimidazo[1,2-a]pyrazine (5.5g, 24.1 mmol) and stined at 90C for 5h. The reaction mixture was cooled and partitioned between ethyl acetate and water. The organic layer was washed with water, brine, dried over anhydrous sodium sulfate and concentrated underreduced pressure to get the crude product. The crude product was purified by column chromatography (60-120 mesh silica gel and 10- 20% EtOAc in hexane) to obtain 8-methoxy-3- (trifluoromethyl)imidazo[ 1 ,2-a]pyrazine (1 .5g, 29%). LC-MS: 218.3 [M+Hf.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine, and friends who are interested can also refer to it.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; KOTRABASAIAH UJJINAMATADA, Ravi; PANDIT, Chetan; (152 pag.)WO2016/185342; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem