Electric Literature of 4858-85-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4858-85-9, name is 2,3-Dichloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
2,3-Dichloropyrazine 5 (5.0 g, 33.6 mmol) in 28% aqueousammonia solution (20 mL) in a reactor Parrwas stirred at 100 C for17 h. After cooling, the resulting mixture was filtered, the solid waswashed with water and dried in vacuo to afford compound 6 (3.0 g,70%) as a white powder. Rf 0.37 (cyHex/EtOAc 1:1); Mp: 170 C (lit.[43]: 169.4e170.1 C); 1H NMR (400 MHz, DMSO-d6): d 6.83 (bs, 2H,NH2), 7.60 (d,1H, J 2.4 Hz, H5), 7.98 (d, 1H, J 2.4 Hz, H6); 13C NMR(100 MHz, DMSO-d6): d 130.6 (CH), 132.6 (C), 141.4 (CH), 152.7 (C);MS (ESI) m/z (%): 129.8 (100) [MH], 131.8 (40). [MH2].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Marchand, Pascal; Bazin, Marc-Antoine; Pagniez, Fabrice; Riviere, Guillaume; Bodero, Lizeth; Marhadour, Sophie; Nourrisson, Marie-Renee; Picot, Carine; Ruchaud, Sandrine; Bach, Stephane; Baratte, Blandine; Sauvain, Michel; Pareja, Denis Castillo; Vaisberg, Abraham J.; Le Pape, Patrice; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 381 – 395;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem