Application of 762240-92-6, A common heterocyclic compound, 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, molecular formula is C6H8ClF3N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of the acid (VII?) (1.00 g, 2.62 mmol) in THF (5 mL) at 0 C is added carbonyldiimidazole (510 mg, 3.15 mmol) and 10 minutes later triethylamine (0.4 mL, 2.62 mmol), previously solubilised in THF (5 mL), and triazolopiperazine hydrochloride (VIII) (599 mg, 2.62 mmol). The mixture, under an inert atmosphere of N2, is magnetically stirred under reflux for 16 hours until completion, then the mixture is cooled to room temperature, water added and the mixture extracted with toluene. The combined organic phases are dried and evaporated under reduced pressure. 1H NMR (300 MHz, d6-dmso, 100 C.) delta 7.4-7.2 (m, 7H), 6.90 (bs, 1H) 4.97 & 4.90 (AB system, J=12.9 Hz, 2×1H), 4.92 (s, 2H), 4.26-4.14 (m, 3H), 3.97 (t, J=5.5 Hz, 2H), 2.92 & 2.67 (2×dd, J=14.1, 4.9 Hz, 2×1H), 2.83-2.72 (m, 2H).
The synthetic route of 762240-92-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHEMO IBERICA S.A.; Rasparini, Marcello; Tufaro, Roberto Rocco; Minelli, Cosima; US2014/81026; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem