In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 36070-80-1
5-chloropyrazine-2-carboxylic acid (1.00 g, 6.31 mmol),2,2,2-Trifluoroethylamine (687.52 mg, 6.94 mmol),N, N-diisopropylethylamine (3.56 mL, 20.81 mmol),Dissolve O- (7-azabenzotriazol-1-yl) -N, N, N ‘, N’-tetramethyluronium hexafluorophosphate in methylene chloride (30 mL) and stir at room temperature overnight under a nitrogen atmosphere did.Thereafter, saturated aqueous sodium bicarbonate solution was added, extraction was performed with ethyl acetate, and magnesium sulfate was added for dehydration.The magnesium sulfide was removed by suction filtration, the solution was concentrated under reduced pressure, and the composition was purified by silica gel chromatography to give the title compound.(1.10 g, 72.8% yield, white solid)
The synthetic route of 36070-80-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nippon Kayaku Co.,Ltd.; Hasegawa, Shinji; Ueno, Shotaro; Shinko, Daiki; Kobayashi, Takehiko; Miyake, Takaaki; Asano, Shu; Sumi, Takuto; (101 pag.)JP2019/19124; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem