109-08-0, name is 2-Methylpyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Methylpyrazine
General procedure: 4-(Di-2-picolylamino)benzaldehyde (1) (110 mg, 0.36 mmol) and the appropriate methyldiazine derivative (0.72 mmol; 0.36 mmol for 4-methyl-2,6-dipyridin-2-yl-pyrimidine; 0.18 mmol for 4,6-dimethylpyrimidine) were dissolved in anhydrous THF (15 mL). KtBuO (1.44 mmol, 161 mg, 4 eq.) was slowly added at room temperature and the solution was heated under reflux for 15 h. The mixture was allowed to cool and water was added. THF was evaporated and the mixture was extracted with CH2Cl2. The organic layer was dried over MgSO4 and the solvent was removed under vacuum. The crude product was purified by flash chromatography.
The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Achelle, Sylvain; Rodriguez-Lopez, Julian; Bure?, Filip; Robin-Le Guen, Francoise; Dyes and Pigments; vol. 121; (2015); p. 305 – 311;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem