Synthetic Route of 4858-85-9, A common heterocyclic compound, 4858-85-9, name is 2,3-Dichloropyrazine, molecular formula is C4H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 2,3-dichloro compound (1, 1.256 mmol), 10% Pd/C (0.0125 mmol), CuI (0.0125 mmol), PPh3 (0.0502 mmol) and Et3N (1.8844 mmol) in EtOH (4 mL) was stirred for 15 min. To this was added an appropriate terminal alkyne (2, 1.256 mmol), under a nitrogen atmosphere and the mixture was stirred at 60 C for 2-4 h. After completion of the reaction, the mixture was diluted with EtOAc (3 x 10 mL). The organic layers were collected, combined, washed with cold water (2 x 15 mL), dried over anhydrous Na2SO4, filtered and concentrated under vacuum. The crude product was then purified by column chromatography on silica gel using EtOAc / n-hexane as a solvent system.
The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kolli, Sunder Kumar; Nakhi, Ali; Medishetti, Raghavender; Yellanki, Swapna; Kulkarni, Pushkar; Ramesh Raju; Pal, Manojit; Bioorganic and Medicinal Chemistry Letters; vol. 24; 18; (2014); p. 4460 – 4465;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem